Autoimmune Thyroiditis is in type I versus type 2 diabetics
Journal of the Egyptian Society of Endocrinology, Metabolism and Diabetes [The]. 2002; 34 (1-2): 59-68
in English
| IMEMR
| ID: emr-59766
ABSTRACT
to determine the prevalence of autoimmune thyroiditis [AIT] as evidenced by thyroid peroxidase antibodies [TPO-ABs] in both types of diabetes Seventy five subjects from the Main Alexandria University Hospital were selected and divided into 3 groups. Group I included 30 type 1 diabetics. Group II included 30 type 2 diabetics, while group III included 15 healthy subjects of matched age and sex. Thorough history taking and physical examination were done. Fasting plasma glucose [FPG] and glycated haemoglobin [HbA1c] were estimated the following parameters were measured in serum TPO-ABs, tyrosine phosphate-like proteins antibodies [IA2-ABs] and glutamic acid decarboxylase antibodies [GAD-ABs], Also, thyroid stimulating hormone [TSH] and free thyroxine [FT4 levels were measured in all subjects. Type l diabetics had the highest frequency of TPO-ABs positivity [26.7%], while in type 2, it was 10% vs control 6.7%, but it did not reach significant levels. TPO-ABs positivity was significantly associated with higher levels of IA2-ABs and GAD-ABs. It was also significantly associated with elevated TSH levels and insignificantly related to low free T4 levels. Conclusions:
AIT, as evidenced by TPO-Abs, was present in type 1 diabetics and some type 2 with late life onset [LADA], a/though it did not reach significant levels. Results obtained were encouraging for diabetes and AIT prediction and for immunointervention measures to be used in high risksubjects:
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Thyroxine
/
Blood Glucose
/
Thyroiditis, Autoimmune
/
Glycated Hemoglobin
/
Thyrotropin
/
Protein Tyrosine Phosphatases
/
Diabetes Mellitus, Type 1
/
Diabetes Mellitus, Type 2
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J. Egypt. Soc. Endocrinol. Metab. Diabetes
Year:
2002
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