Incidence of helicobacter pylori associated chronic antral gastritis in patients presenting with dyspeptic symptoms at Sindh Govt. Lyari general hospital

ABSTRACT

Recent Studies have proved that H. Pylori, found in gastric Antrum of patients with peptic ulcer disease, is now believed to have a pathophysiologic role in Gastritis. Aim of the study was to observe and detect during routine upper G.I. Endoscopic carried out at the S.GLyari Gen. Hospital, in patients presenting with dyspepsia, the incidence of H. Pylori, confirmed by Antral Biopsy method for Urease test or histopathology.diagnostic Upper G.I. Endoscopics were performed on 61 patients presenting with Dyspepsia in the period of 18 months from February '98 to August'99. Routine Antral Biopsies were taken in all patients, in all patients, in which gastritis was seen and urease test done all of them, and biopsy was also sent for Histopathology. Out of the 61 Endoscopies done on patients presenting with symptoms of Dyspepsial Epigastric pain, 30 patients had Antral gastritis [17 were H.Pylori+ve and 13 were H.Pylori-ve], 19 were essentially normal, 02 had duodenal ulcer. Triple Regime Treatment, comprising Omeprazole, Clarithromycin and Amoxicillin was given to H.Pylori+ve patients for two weeks and of these 73.3% responded very well. Incidence of aprox. 56.6% H.Pylori associated chronic Gastritis was observed. The diagnostic methods of upper G.I.Endoscopies plus antral biopsies for HelicoUrease test/Histopathology have high specificity and sensitivity