Medical Journal of the Islamic Republic of Iran. 2002; 16 (3): 169-173
in English
| IMEMR
| ID: emr-60129
ABSTRACT
The aim of this study was to evaluate the immune system and lymphocyte function in 41 Iranian [beta]-thalassemic patients and 50 controls, ages ranging from 2 to 18 years. The patients consisted of 20 splenectomized and 21 non-splenectomized patients. They were treated with Desferal, and had received repeated blood transfusion. Laboratory investigations included measurement of total T lymphocytes, active T lymphocytes, B-lymphocytes and function of lymphocytes treated with PHA. In this study we observed a significant reduction of active T lymphocytes and total T lymphocytes in the patient group compared to controls [p<0.005 and p<0.001], but there was no significant difference between splenectomized and non-splenectomized patients. Also in both groups, lymphocyte function was reduced against PHA [phytohemagglutinin] compared with the controls, and the numbers of B cells were increased. These results lead to the conclusion that the deficient immune system in [beta]-thalassemia causes infectious diseases, which finally leads to death. Therefore, stimulation of the immune system as well as clinical treatment may prevent infectious disease in patients with [beta]- thalassemia
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Phytohemagglutinins
/
Splenectomy
/
Blood Transfusion
/
B-Lymphocytes
/
T-Lymphocytes
/
Cytomegalovirus
/
Immune System
/
Immunity, Cellular
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Med. J. Islamic Rep. Iran
Year:
2002
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