Plasma homocysteine levels in cerbrovascular strokes

Seventy adult subjects were included in this study and subdivided into four groups: The first group included 10 healthy lean subjects as a control group, the second group included 20 patients with high risk factors as diabetes mellitus, hypertension, hypercholesterolemia and/or smoking, the third group included 20 patients with cerebrovascular stroke and having one or more of the risk factors, while the fourth group included 20 patients with stroke having none of the above-mentioned risk factors. This study showed that homocysteine was significantly elevated in the three different groups of patients compared with the control group. Although homocysteine levels were higher in both groups of patients with stroke compared with the non- stroke patients with risk factors, the difference was not statistically significant. Also, this study showed that there were significant elevated levels of cholesterol, triglycerides, fasting blood glucose and glycated hemoglobin in both groups of patients with risk factors compared with the control group or the group of patients with stroke, but without having risk factors other than hyper homocysteine. In addition, the study showed that there was a significant positive correlation between homocysteine and age, body mass index [BMI], blood glucose, glycated hemoglobin, total cholesterol and low lipoprotein cholesterol