Chronic anovulation: its phases and the associated hormonal perturbation

ABSTRACT

A total of 230 cases of infertility due to anovulation was selected for this study. Amenorrhea, PCOs, galactorrhea and hirsutism were clinically associated with these cases. FSH, LH, PRL, E2, free testosterone and DHEA-S04 were assayed in all cases by IRMA and RIA methods. One- and two-gravida was found in 102 cases and nulligravidae in the rest. Anovulation was proved in all cases by endometrial biopsy. All cases were assessed clinically for the progress of the disease and to exclude other causes of infertility. It was concluded that chronic anovulation must be considered a single clinico endocrinal entity with variable phases. Accordingly, hormonal assay is essential to confirm the diagnosis and to determine the state of chronicity or its phase