New Egyptian Journal of Medicine [The]. 2002; 27 (Supp. 1): 26-34
in English
| IMEMR
| ID: emr-60317
ABSTRACT
A series of 40 females complaining of infiltrating duct carcinoma was included in this study. Clinicopathological background, histological grade and immunohistochemical staining for p53, HER-2/neu as well as estrogen and progesterone receptors were analyzed. The results showed that 14 cases were positive to p53, 12 were positive to HER-2/neu, 30 were positive to estrogen receptor and 22 were positive to progesterone receptors. The statistical analysis showed a positive correlation between p53 protein staining with tumor grade and an invasive relation to the hormonal status; whereas, HER-2/neu showed a significant correlation to the lymph node status. No correlation was detected between p53 protein, HER-2/neu protein expression and progression free survival. HER-2/neu protein-positive patients showed an improved response to anthracycline-containing regimen. A complete response was attained in 5% of the cases, partial response in 25%, stationary disease in 60% and 10% of the cases had progressive course
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Prognosis
/
Recurrence
/
Immunohistochemistry
/
Carcinoma, Ductal, Breast
/
Neoplasm Metastasis
/
Neoplasm Staging
Limits:
Female
/
Humans
Language:
English
Journal:
New Egypt. J. Med.
Year:
2002
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