Ribavirin induces immunomodulation in chronic hepatitis C therapy

Sanaa M., Kamal; Ennayah, Shoukry; Mai, Abdel Allem; Heba, Shaker; Ashraf, Adel Hamid

Sanaa M., Kamal; Ennayah, Shoukry; Mai, Abdel Allem; Heba, Shaker; Ashraf, Adel Hamid.

New Egyptian Journal of Medicine [The]. 2002; 27 (Supp. 1): 45-54

in English | IMEMR | ID: emr-60320

ABSTRACT

ABSTRACT

To investigate the effects of ribavirin on hepatitis C virus [HCV] specific T-helper cell responses and the expression of interleukin-12 receptor-beta-1 and beta-2 chains on CD4+ T cells, peripheral blood mononuclear cells from 56 patients with proven chronic hepatitis C were incubated with or without ribavirin [0.1 mug/ml]. The results suggested that ribavirin induces up-regulation and differentiation of CD4+ T cells through the up-regulation of interleukin-12 receptor beta-2 chain

Subject(s)

Humans; Male; Female; CD4 Lymphocyte Count; Biopsy; Histology; Interleukin-10; Interleukin-12; Liver Function Tests; Receptors, Interleukin; Chronic Disease; Adjuvants, Immunologic

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Index: IMEMR (Eastern Mediterranean) Main subject: Biopsy / Adjuvants, Immunologic / Chronic Disease / Interleukin-10 / Receptors, Interleukin / Interleukin-12 / CD4 Lymphocyte Count / Histology / Liver Function Tests Limits: Female / Humans / Male Language: English Journal: New Egypt. J. Med. Year: 2002

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