Prevalence des auto anticorps anti - GAD chez des enfants Tunisiens diabetiques de type 1.
Tunisie Medicale [La]. 2002; 80 (5): 281-5
in French
| IMEMR
| ID: emr-61097
ABSTRACT
The prevalence of GAD antibodies and its correlation with some autoimmune markers ICA [islet cells antibodies]. Antinuclear antibodies, thyroid antithymune and antimicrosomes antibodies., were studied in 84 Tunisian type 1 diabetic children. The prevalence of GAD antibodies was 51.2% and decreased as a function of increasing duration of the disease. Their frequency was 84.6% in children with newly diagnosed diabetes [within 6 months of diagnosis] and only 29.41% in those with a longer duration of the diabetes [more than 5 years]. ICA were present less frequently [21.4% of the children]. 10.7% of the studied samples were positive with the two antibodies [GAD ab ICA], and 40% were positive only with GAD antibodies. We conclude that the GAD antibodies seems to be more associated to the development of type 1 diabetes than ICA. They are detected more frequently in patients with long standing disease, that's make their determination very interesting as diagnostic and predictive marker
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Autoantibodies
/
Autoimmunity
/
Child
/
Antibodies, Antinuclear
/
Prevalence
/
Islets of Langerhans
/
Glutamate Decarboxylase
Type of study:
Prevalence study
Limits:
Female
/
Humans
/
Male
Language:
French
Journal:
Tunisie Med.
Year:
2002
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