Plasma ghrelin concentrtions in: lean and obese individuals: effects of food intake, dieting and partial gastrectomy

ABSTRACT

Ghrelin is a recently discovered hormone synthesized predominantly by the stomach. It has been reported to have adipogenic and orexigenie actions and induces weight gain in addition to its Gil-releasing properties. This work aimed at studying the Ghrelin levels in both lean and obese individuals, effect of feeding, dieting, gastric resection on plasma Ghrelin levels. 30 individuals were the subjects of this study, using radio immunoassay method for measurement of plasma Ghrelin levels. There were high significant plasma Ghrelin level in lean group compared to both obese and partial gastrectomy groups[p<0.01, p<0.05 respectively]. Plasma [Ghrelin level decreased significantly after feeding [p<0.01], and increased significantly post-dieting loss of weight [p<0.05]. In conclusion, Ghrelin is a hormone produced mainely by the stomach, has a role in the long-term regulation of body weight, promote feeding. prevent further weight and energy loss