hepatoprotective effect of Cinnamon bark oil and Niegella Sativa L. Seed oil in comparison to N- acetyl cysteine in rats treated with toxic dose of paracetamol

ABSTRACT

Paracetamol, in toxic doses is associated with extensive liver damage. This study was undertaken to investigate the hepatoprotective effect of cinnamon bark oil [CBO] and nigella sativa oil [NSO] in comparison to N- acetyl cysteine [NAC] in rats treated with toxic doses of Paracetamol [PCM]. The study included 6 groups, each group consists of 6 rats control group received distilled water orally. Rats treated with toxic dose of PCM [400 mg/kg] three groups received NAC [800 mg/kg], CEO [300 mg/kg] and NSO [288 ml/kg] as antidotes 2 hours after PCM intoxication. The last group received CEO 8 hours post PCM intoxication Twenty-four hours after treatment the rats were sacrificed and blood was collected. The 3 antidotes decreased the activity of hepatic enzymes [AST and ALT] and billirubin compared to the PCM treated rats [P < 0.001]. Liver architecture showed improvement in the antidote treated groups compared to the PCM treated rats. The antidotes enhanced the elevation of the antioxidants [Glutathione [GSH], GSH-Peroxidase GSH-Reductase and Superoxide dismutase [SOD]] compared to their levels in PCM treated rats [P <0.001]. It is concluded that CBO either given early or late and NSO have hepatoprotective effect as well as that of NAC