Role of zinc in hepato- and nephrotoxic effects of chlorpyrifos. A biochemical, trace elemental and histological study

ABSTRACT

Chlorpyrifos [CPF] is one of the most potent broad-spectrum organophosphates used frequently against cockroaches and other structural pests. Repeated exposure to chlorpyrifos may endanger many populations with resultant toxic effects on many organs. Recent studies revealed that zinc might modulate these toxic effects. This work was carried out to ascertain the toxic effects of CPF on the rat liver and kidney. Also, the possible protective role of zinc had been evaluated. The study was conducted on 70 adult male albino rats divided into seven equal groups. Group I negative control, group II distilled water, group III zinc, group IV low dose CPF, group V high dose CPF, group VI zinc and low dose CPF and group VII zinc and high dose CPF. The duration of the study was eight weeks then hepatic, renal profiles, plasma zinc, copper, MDA, SOD, GSH, GSSO were measured. Also, histological examination of liver and kidney was done. The obtained biochemical and histological results revealed hepatic and renal toxic effects induced by CPF in a dose dependent manner. Zinc supplementation resulted in a remarkable protective effect at the biochemical and histological levels. Further studies on zinc supplementation to either patients or workers exposed to CPF are recommended