Novel leu-enkephalin analogue with anti-tumor activity
Arab Journal of Pharmaceutical Sciences. 2003; 2 (6): 11-20
in Arabic
| IMEMR
| ID: emr-61579
ABSTRACT
The goal of this study was to evaluate the anti-tumor activity of two Enkephalin analogues designed and synthesized using a conventional solution method. The anti-tumor activity of these two analogues was studied in-vitro following National cancer institute [NCI] protocol [USA]. The results confirmed that the synthesized Leu- Enkephalin analogue [analogue 1] have a positive effect on all cell lines tested indicating its effectiveness as anti-tumor compound on many cancers especially those of lungs, colon and breast. Met-Enkephalin analogue [ana1ogue II] showed no effect on any type of tumor cells tested. In conclusion analogue I can be considered as a novel promising anticancer compound
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Enkephalin, Leucine
/
Enkephalin, Methionine
/
Enkephalins
/
Antineoplastic Agents
Language:
Arabic
Journal:
Arab J. Pharm. Sci.
Year:
2003
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