Syntheses and anticonvulsant activity of N4-substituted triazolylthiazoles
DARU-Journal of Faculty of Pharmacy Tehran University of Medical Sciences. 2003; 11 (2): 74-8
in English
| IMEMR
| ID: emr-61795
ABSTRACT
Due to the good anticonvulsant activity of various 1,2,4-triazoles, several new N4-substituted triazolylthiazoles were prepared by the general method for 1,2,4-triazole ring closure. Anticonvulsant activity of compounds was measured against pentylenetetrazole-induced seizures in mice by intraperitoneal injections of different doses of the test compounds. Pretreatment of animals with flumazenil [10 mg/kg, i.p.] as a benzodiazepine receptors antagonist did not have any significant effect on anticonvulsant activity of the test compounds. These results demonstrate that the anticonvulsant activity of N4-substituted triazolylthiazole agents is not probably mediated by direct interaction with benzodiazepine receptor complex
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pentylenetetrazole
/
Triazoles
/
Flumazenil
/
Mice
/
Anticonvulsants
Limits:
Animals
Language:
English
Journal:
J. Fac. Pharm. Tehran Univ. Med. Sci.
Year:
2003
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