Pathogenetic role of erythrocyte complement-receptor-1 [CR1] and L selectin in SLE patients

ABSTRACT

To evaluate the role of erythrocyte CR1 and L-selectin in the pathogenesis of SLE and try to find out any correlation between them with some clinical and laboratory associated data. Thirty patients diagnosed as SLE according to ACR criteria with mean age 23.6 +/- 6.9 in addition to 10 apparently healthy normal [age and sex matched] subjects as a control group were included in this study. There were higher values of erythrocyte CR1 percentage in controls more than patients [p<0.05], while this could not be found as regards level of L-selectin [p>0.05]. A significant association was found between erythrocyte CR1 percentage with fever and arthralgia [p<0.05], but this could not be found as regards the other clinical findings. There was a significant association between the level of L-selectin with arthralgia and cardiac affection [p<0.05], but this was not found with other clinical findings. Significant correlations were found between erythrocyte CR1 percentage and serum creatinine level, urinary pus cells ESR and platelets counts [p<0.05], while no correlations were found between L-selectin level and other laboratory findings. No correlations were found between erythrocyte CR1 percentage and L-selectin level with disease onset, duration or disease activity score. Both erythrocytes CR1 and L-selectin [to a lesser extent] have a crucial role in the pathogenesis of SLE as regards joint and kidney affection through IC mediated vasculitis