Dependence of quality of thallium - 201 on irradiation data

ABSTRACT

Thallium-201 is produced through 203Tl [p, 3n] 201pb 201Tl reaction by cyclotron. This radioisotope has known as one of the cyclotron radioisotopes which is used for myocardial perfusion in the coronary artery disease, Tl-201 after chemical purification and quality control in the form of 201Tl-chlorid is ready to send to the hospitals. In this work the effect of the proton energy on quality of Tl-201, was studied. Radionucleidic purity was determined by high purity Ge [HPGe] detector Gamma spectrometer, in production time and after one half-life [73h]. The targets were coated with Enriched Thallium-203 [97%]. The Variation of thickness of targets was 18.3 +/- 1.3micro m. The different energies of bombardment on quality of Tl-201 and Tl-200, Tl-202, and Pb-203 [as impurity] were studied. The results have shown that optimum energy for proton was 28.5 MeV. The variation energy of bombardment can change the purity of Tl-201 but all results were in the standard range according to the United States Pharmacopoeia [USP] and European Pharmacopoeia