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Peripheral blood stem cell transplantation in children with B-thalassemia major
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2003; 13 (4): 204-206
in English | IMEMR | ID: emr-62523
ABSTRACT
To share the preliminary data on stem cell transplantation in Pakistan.

Design:

This is a single center retrospective analysis of the outcome of allogeneic peripheral blood stem cell [PBSC] transplantation in b-thalassemia major patients. Place and Duration of Study Bismillah Taqee Blood Diseases Centre, Karachi; a tertiary care hematology center from September 1999 to September 2002. Patients and Twelve patients with b-thalassemia major received allogeneic PBSC transplantation from HLA identical sibling donors except in one case where mother was the donor. All patients received busulphan and cyclophosphamide conditioning therapy and cyclosporin A / methotrexate for graft versus host disease [GVHD] prophylaxis. Donors were primed with G-CSF for 4 days and stem cells were harvested using Haemonetics MCS + cell separator on 5th day. All patients received G-CSF starting from day + 4 until their neutrophil count rose to normal. Engraftment was achieved in all patients except one who required a second dose of bone marrow graft on day +21. Median time to achieve absolute neutrophil count of > 0.5 x 109 /l was 9.0 days [range 8 ' 31 days] and platelet count of > 20 x 109 /l was 14 days [12 ' 35 days]. Acute GVHD was seen in 3 patients, one patient had grade IV gut GVHD; another patient had grade III gut GVHD while third patient had grade II skin GVHD. Median hospital stay was 29 days. Six patients were well and transfusion independent 3 to 36 months posttransplant. One episode of primary graft failure required a second dose of bone marrow harvest. Another episode of graft rejection received two doses of donor lymphocytes infusion. There were 4 deaths due to grade IV gut GVHD because of uncontrolled systemic Candida infection and one due to hepatic veno-occlusive [VOD] disease. Allogeneic peripheral blood stem cell transplantation can be safely and economically carried out in Pakistan. Although there had been 4 deaths during 36 months follow-up, with increasing understanding and experience the outcome is expected to improve
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Index: IMEMR (Eastern Mediterranean) Main subject: Transplantation, Homologous / Cell Separation / Child / Hematopoietic Stem Cell Transplantation Limits: Female / Humans / Male Language: English Journal: J. Coll. Physicians Surg. Pak. Year: 2003

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Index: IMEMR (Eastern Mediterranean) Main subject: Transplantation, Homologous / Cell Separation / Child / Hematopoietic Stem Cell Transplantation Limits: Female / Humans / Male Language: English Journal: J. Coll. Physicians Surg. Pak. Year: 2003