Effect of chronic renal impairment on adrenomedullin levels in rats

ABSTRACT

Adrenomedullin [ADM] is a novel and potent vasodilator peptide with a partial structural homology to calcitonin gene related peptide [CGRP]. This study was carried out on 18 albino rats divided into three equal groups [n=6]. Group I sham operated normal rats; group II subtotally nephrectomized [SN X] rats sacrificed four' weeks postoperatively Group III SNX rats sacrificed eight weeks postoperatively. All these groups were studied for the following parameters, blood urea, plasma nitrite, plasma and tissue adrenomedullin concentrations. This study revealed a significant elevation in plasma urea level in groups II and III compared to group I also groups II and III showed a significant rise in both plasma and kidney tissue adrenomedullin levels while plasma and urinary levels of nitrites showed significant decrease as compared to controls