Role of circulating fosciola antigens and IgG4 isotype in assessment of cure from fascioliasis
Journal of the Egyptian Society of Parasitology. 2003; 33 (2): 516-70
in English
| IMEMR
| ID: emr-62865
ABSTRACT
Sixty-eight individuals were included in this study; 30 of them were presented with Fasciola infection, 20 were infected with other parasites [infected control group] and 18 individuals were parasite- free [normal control group]. For all groups, stool analysis by modified formol-ether technique and Kato thick smears for egg counts and the circulating Fasciola antigens [CFAgs] and anti-Fasciola IgG4 isotype were estimated by ELISA technique. Complete blood count, liver functions tests and abdominal ultrasonography were performed for all Fasciola-infected patients. Patients with fascioliasis received a myrrh-derived drug [mirazid] in a dose of 10 mg/kg b. Wt., one hour before breakfast for six consecutive days. Re-measuring of the above parameters was performed one and three months after therapy. The detection of CFAgs was found to be a useful marker for the assessment of core. No cross-reaction was observed between Fasciola and other parasites using CFAg [100% specificity]. The level of these antigens was positively correlated with the signs of cure, parasitologically, clinically or ultrasonographically. The detection of IgG4 isotype was found to be a more sensitive and accurate immunodiagnostic tool for fascioliasis, but it was not a useful marker for the assessment of cure. Mirazid drug possesses a high therapeutic efficacy [100% cure rate] on fascioliasis without remarkable side effects
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Immunoglobulin G
/
Ultrasonography
/
Treatment Outcome
/
Eosinophils
/
Leukocyte Count
/
Liver Function Tests
/
Antigens, Helminth
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J. Egypt. Soc. Parasitol.
Year:
2003
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