Diagnosis and eradication of helicobacter pylori in patients with duodenal ulceration in the community
JPMA-Journal of Pakistan Medical Association. 2003; 53 (3): 90-94
in English
| IMEMR
| ID: emr-63103
ABSTRACT
To determine the value of Helicobacter pylori [Hp] serology in diagnosis of active Hp infection in patients with documented duodenal ulcer [DU] and to directly compare the efficacy and side-effects profiles of metronidazole or tinidazole in a triple therapy regimen to eradicate active Hp infection. Prospective, single-blinded, randomised trial. One hundred patients from General Practice with documented DU and Hp seropositivity had a C14 Urea Breath Test [UBT]. Those who tested positive were randomised to receive one-week, twice daily omeprazole 20 mgs and clarithromycin 250 mgs in combination with metronidazole 400 mgs [OCM] or tinidazole 500 mgs [OCT]. Eradication was confirmed by a repeat UBT. Eighty five sero-positive patients had a positive pre-treatment UBT. On intention to treat basis, OCT [100%] had a significantly better eradication rate than OCM [87.8%], p = 0.023. There was no difference in side effects. [1] Positive Hp serology in patients with DU does not always mean active infection and [2] for patients in the community with active Hp and DU disease OCT is significantly better than OCM for eradicating Hp
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Randomized Controlled Trials as Topic
/
Helicobacter Infections
/
Drug Therapy, Combination
/
Duodenal Ulcer
/
Metronidazole
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J. Pak. Med. Assoc.
Year:
2003
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