Diurnal pattern of plasma endothelin-1: effect on endothelium-dependent vasodilatation in patients with stable angina pectoris
Mansoura Medical Journal. 2003; 34 (1-2): 207-230
in English
| IMEMR
| ID: emr-63418
ABSTRACT
This study included two groups of patients Group I included 20 patients with stable angina pectoris [SA] [18 men and 2 women, aged 50.51 +/- 8.29 years] and group II included 20 healthy subjects [17 males and 3 females, aged 48.11 +/- 6.31 years] taken as a control group. Flow-mediated vasodilatation [FMD] of the brachial artery [a surrogate for endothelium-dependent vasodilatation] was determined by ultrasound at 8 a.m. and 8 p.m. Also, carotid artery intima-media thickness [IMT] was determined by ultrasound. The plasma levels of C- reactive protein [CRP] and ET-1 were determined at 8 a.m. and 8 p.m. The study included that the normal subjects had diurnal variation in endothelium-dependent vasodilatation that may counteract other, potentially adverse, diurnal variations in the hemodynamic and other parameters. In contrast, patients with SA showed a loss of this protective mechanism. No diurnal variation in plasma CRP was found to explain this finding. Diurnal variation in plasma ET-1 levels is likely one of the mechanisms involved in the pathogenesis of this phenomenon
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Vasodilator Agents
/
C-Reactive Protein
/
Biomarkers
/
Circadian Rhythm
/
Endothelin-1
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Mansoura Med. J.
Year:
2003
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