Neural tube defects in newborns in the South-East of the Caspian sea border [Gorgan, Iran 1998-2000]

ABSTRACT

Neural tube defects [NTD] are one of the most important malformations of newborns. The aim of this research is to determine the rates of NTD, anencephaly and spina bifida cystica and the relations of these abnormalities to the factors including sex, race, ethnicity, maternal age and familial marriage in the south-east of the Caspian Sea border. A three-year descriptive-analytic and cross-sectional study was carried out on 19545 newborns delivered in Dezyani hospital in Gorgan during 1998-2000. From the total sample population [19545], the NTD rate was 3.12 per 1000 deliveries. In males the rate was 2.49 per 1000, in females 3.79 per 1000, and the female to male ratio was 1.441. The rate of anencephaly and spina bifida was 1.25 per 1000 and 1.74 per 1000 respectively. In regard to different races the NTD rate was 7.48 per 1000, 9.5 per 1000, and 2.35 per 1000 among Turkmans, Sistanis and Farses, respectively. It can be concluded that there is a higher rate of NTD in this region that may be due to the race-ethnicity and the ecological variations