Evaluation of two types of fibrin sealants as a haemostatic agent in the management of hepatic injuries: an experimental comparative study in an animal model

ABSTRACT

The present study was carried out on 40 female albino rabbits [1 kilogram in weight] in the animal laboratory of the National Cancer Institute. General anaesthesia was administered to all rabbits. The abdomen was entered through an upper midline incision and the liver was exposed. The scalpel was used to inflict a 2 cm long wound in the liver parenchyma deep enough but short of the posterior Glisson's capsule. The rabbits were divided into 2 equal Groups; in group [1] fibrin glue made from platelets and bovine thrombin was applied to the hepatic tear; while in group [2] fibrin glue made from platelets and human thrombin was applied to the liver tear. The time needed to achieve haemostasis was recorded in each group. Both types of fibrin sealants were successful to achieve haemostasis well as healing of the liver tear. However, the time needed to achieve haemostasis was significantly shorter in group [1] [bovine thrombin group]. It was concluded that both agents could be an attractive solution in the management of hepatic injuries especially in the modern era of surgical laparoscopy