Nonalcoholic steatohepatities in type 2 diabetes mellitus

ABSTRACT

The present study was conducted on 22 females with type 2 diabetes mellitus and hepatomegaly in whom ultrasonography showed bright hepatomegaly, in addition to 20 healthy controls of comparable age and sex. Patients with evidence of hepatitis C, B, metabolic liver disease or autoimmune hepatitis were excluded. None of the patients and controls was alcohol drinker. In all patients and controls, fasting and two-hour postprandial plasma glucose, HbA1c, bilirubin, aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase, cholesterol and triglyceride were done. Liver biopsy using Baxter cut needle [G14] was done in patients only. It can be concluded that nonalcoholic steatohepatitis [macrovesicular steatosis and lobular inflammation alone] occurs in 31.8% of patients with hepatic steatosis in type 2 diabetes mellitus. Hepatocyte necrosis and progression to hepatic fibrosis may occur in some cases. Progression to fibrosis may occur in patients with inadequate glycemic control