Endogenous nitric oxide and lipid peroxidation in ischemic heart disease

ABSTRACT

This study was performed on 30 patients with ischemic heart disease [IHD] categorized according to the stability of chest pain into three groups A unstable angina group [n = 10], B stable angina group [n = 10] and C silent ischemia group [n = 10]. A significant decrease in total serum nitrite [NO2-] and nitrate [NO3-] and a significant increase in serum malondialdehyde [MDA] were found in all patients groups versus the control group. The same findings were noticed in the unstable angina group versus both the stable angina and the silent ischemia group. The sex, type of arrhythmia, presence or absence of ST segment depression in electrocardiographic Holter monitoring and the echocardiographic findings did not affect the mean levels of both parameters. A significant negative correlation was found between both measured parameters