Inhibition of lipid peroxidation by anti-inflammatory drugs, human plasma and serum

ABSTRACT

Serveral non-steroidal anti-inflammatory drugs known to inhibit prostaglandin [PG] biosynthesis were also found to inhibit lipid peroxidation. Similarly, endogenous inhibitors of PG biosynthesis, such as human blood plasma, serum and plasma - globulin fraction, also inhibited lipid peroxidation. These results throw new light on the mechanism of action of anti-inflammatory drugs and also open up the interesting possibility that the inhibition of lipid peroxidation may be a component of anti-inflammatory response to these drugs