Medical treatment of nasal polyposis with intranasal antifungal solution: preliminary findings

ABSTRACT

The aim of this work was to evaluate reported success in treatment of nasal polyposis with local intranasal antifungal preparations. Forty three patients suffering from nasal polyposis were randomly included in this prospective study. After clinical staging of the extent of nasal polyposis, the patients were randomized into three treatment groups. Group I received topical steroid nasal spray, Group II patients were treated with nasal irrigation with Amphotericin B solution and Group III patients were treated with Amphotericin B and topical steroid spray. The efficacy of treatment was evaluated objectively through endoscopic assessment of the post treatment stage of nasal polyposis. In the population of 26 patients who received amphotericin B [group II and III], 12 patients [46%] achieved complete success and disappearance of the nasal polyps, while 15 patients [58%] had partial success with improvement of their pre-treatment clinical staging. The smaller polyps were easier to treat yielding a success of 78% in stage I, versus 42% and 9% in stage II and III. In conclusion, the results of this preliminary study suggest that intranasal irrigation with amphotericin B solution is safe and effective in treatment of stage I and II nasal polyposis