Ultrastructural changes in the endothelial cells of the endoneurial blood vessels of the sciatic nerve of albino rats after crush injury

ABSTRACT

This study included 14 male albino rats. The sciatic nerves of 12 rats were subjected to crush injury, while 2 rats were used as controls. The sciatic nerves were exposed and the parts distal to the crush injury were taken. The specimens were prepared for study by electron microscope. The results of the present work showed that after crush injury, there was an increase in the permeability of the endothelial cells of blood vessels. Also, the intercellular junctions of the endoneurial blood vessels were distended with the absorbed fat globules. The current study showed that transendothelial transmission was increased leading to the appearance of large electron lucent fat globules. After six weeks of crush injury, there was a marked decrease in the permeability of the endoneurial blood vessels. It could be concluded that after the first week of peripheral nerve injury, the absorption through the endothelial cells was increased. Then, the absorption showed a marked decrease till the sixth week