potential role of nonsteroidal anti-inflammatory drugs [NSAIDS] in chemopreventtion of cancer

ABSTRACT

To find out the probable effects of Nonsteroidal anti-inflammatory drugs [NSAIDs] in the preventation and treatment of cancer. Design: The influence of NSAIDs on Fibrosarcoma cell line was investigated by using an in vitro cytotoxicity assay, Terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling [TUNEL] assay and gelatin zymography. Setting: Department of Pathobiology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences. Cytotoxicity analysis of Diclofenac revealed much higher cell death than other examined agents. A potenet apoptotic influence of Diclofenac was also confirmed by data obtained from TUNEL assay. Dose-dependent inhibitory effects on Matrix metalloproteinases [MMPs] was seen in higher degree in Diclofenac compared with other examined NSAID[Piroxicam] and a synthetic glucocorticoid [Dexamethasone]. based on our data, the induction of apoptosis together with MMPs inhibition could be indicative of cancer treatment, thus Diclofenac might be considered as a chemopreventative agent in cancer