p53 Immunostaining in benign and malignant effusions
Pakistan Journal of Medical Sciences. 2003; 19 (1): 33-35
in English
| IMEMR
| ID: emr-64148
ABSTRACT
To evaluate p53 immunostaining as a marker of malignancy in pleural and peritoneal effusions and to compare the results with HE staining. Design:
Pleural and peritoneal effusion samples were obtained from patients suffering from benign and malignant diseases. H and E staining and p53 immunostaining were performed on smears prepared from these samples.Setting:
The samples were obtained from patients admitted in Mayo Hospital, Services Hospital, Gulab Devi Chest Hospital and Institute of Nuclear Medicine and Oncology [INMOL].Subjects:
One hundred cases having either pleural or peritoneal effusions were selected. Fifty of these cases were positive for malignant cells on H and E staining. Fifty cases contained only mesothelial cells. Main outcomemeasures:
To compare the specificity and sensitivity of p53 immunostaining with HE stain as a diagnostic marker of malignancy. Out of the 50 malignant cases, 31 [62%] were found to be p53 positive. None of the benign cases showed positive staining. p53 was found to have a specificity of 100%, sensitivity of 62%, a positive predictive value of 100% and a negative predictive value of 72.4%.Conclusions:
p53 is a highly specific and moderately sensitive marker of malignancy
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Staining and Labeling
/
Ascitic Fluid
/
Pleural Effusion, Malignant
/
Cell Biology
/
Neoplasms
Limits:
Humans
Language:
English
Journal:
Pak. J. Med. Sci.
Year:
2003
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