Comparative effeicacy and potency of snake venom, mitomycin-C and cyclophosphamide for RNA and DNA inhibition in breast cancer

ABSTRACT

Anti-proliferating effect of the cobra venom throughh the meassurement of tissue nucleic acids [RNA and DNA] in breast cancerr has been studied and compared to that of cyclophosphamide and mitomycin-C. The venom and other anti-neoplastic were incubated singly as well as in combination for 30 minutes at 37 RNA and DNA with the chemotherapeutic drugs wheras, a significant fall [p<0.001] occurred by the cobra venom. Varying concentrations of the vemon produced not very much change but 25 mirco g/ml concentration has evidently brought the maximum effect against the drugs as well as the controls. From this it may be said that though the drugs failed to bring any significant reductions in in vitro while venom has proved to be an active inhibitor of the nucleic acids in breast cancer. It may therefore be further studied as an alternative weapon to be tested in this disease