Altered regulation of platelet aggregation in renal disorders

ABSTRACT

The activity of endogenous inhibitors of platelet aggregation [EIPA] was measured in the plasma of 19 patients with renal disorder [RD]. Similar studies were conducted in 16 healthy subjects. The plasma of 12 RD patients stimulated platelet aggregation [P<0.005] and had negative EIPA activity. Plasma of 7 out of 19 RD patients exhibited EIPA activity which was lower compared to healthy subject [P<0.001]. All RD patients had abnormally, low levels of plasma albumin [a part of EIPA activity] as compared to normal [P<0.01]. The patients who had low or negative EIPA activity had platelets which were highly sensitive to induction of aggregation by adenosine-5' diphosphate [P<0.001] or adrenaline [P<0.05]. Our data suggests that low plasma EIPA activity in patients with RD may be an important factor in their hypersensitivity to platelet aggregating agents and could contribute to the thrombotic tendency