Study the role of insulin like growth factor-1 [IGF-1] and insulin like growth factor binding protein-1 [IGBP-1] and hormonal pattern in polycystic ovary syndrome [PCOS]

ABSTRACT

Serum insulin, insulin-like growth factor-1 [IGF-1], insulin-like growth factor binding protein-1 [IGBP-1] and some other hormones were assayed in PCOS patients [n=30] and their weight-matched controls [n=30]. Serum insulin levels were found to be significantly higher in PCOS patients when compared to normal control women, serum IGF-1 levels showed no statistically significant difference between PCOS patients and normal control women, serum IGFBP-1 levels were found to be significantly lower in PCOS patients when compared to normal control women. In conclusion, insulin and insulin-like growth factor family seem to be involved in the pathogenesis of PCOS through modulation of serum IGF-1 levels mediated by changes in IGFBP-1 concentration