Phase II multicenter study of irinotecan and 5-fluorouracil/leucovorin as a front line therapy in advanced colorectal carcinoma
Scientific Medical Journal. 2003; 15 (1): 21-35
in English
| IMEMR
| ID: emr-64890
ABSTRACT
This multicenter phase II study was designed to assess the efficacy and tolerability of the combination of irinotecan with bolus 5-FU and calcium leucovorin [LV] as a front line therapy for advanced colorectal cancer [CRC]. Patients with histologically proven advanced CRC and at least one measurable lesion, with age range 18-75 years, with a performance status of <2, normal baseline biochemical values and no prior chemotherapy [apart from adjuvant] were selected. The treatment regimen was formed of weekly CPT-11 [125 mg/m2] i.v. infusion, 5-FU [500 mg/m2] bolus i.v. and LV [20 mg/m2] i.v. for four weeks [two weeks, followed by two weeks rest, this constitute one cycle]. Treatment continued till either complete remission or disease progression or failure
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Leucovorin
/
Follow-Up Studies
/
Treatment Outcome
/
Drug Therapy, Combination
/
Fluorouracil
/
Kidney Function Tests
/
Liver Function Tests
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Sci. Med. J.
Year:
2003
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