Correlation between timing of wounds and the level of soluble intercellular adhesion molecule type 1 [sICAM-1] in traumatized individuals

ABSTRACT

Cytokines are important in the control of wound healing. Many cytokines could be useful for the determination of wound age. The most important of these cytokines are the growth factors and adhesion molecules. Thirty traumatized individuals of both sexes were subjected to this study and were divided, according to the degree of injury severity score [ISS], into three groups; mild, moderate and severe trauma groups; each group consisted of ten patients. Each group is consisted of ten patients. Each group is further subdivided, according to sampling time, into three subgroups within the 1[st] 24 hours of admission, on the third day, and on the fifth day of admission. The control group consisted of six persons. The present study was conducted to correlate between the level of the soluble intercellular adhesion molecule type-1 [sICAM-1] and the timing of wounds in traumatized individuals. The level of sICAM-1 was measured in plasma using the ELISA technique and was estimated in relation to the time passed since infliction of injury on the 1[st] day of admission, on the 3[rd] day and on the 5[th] day. A significant increase was noticed in all subgroups when compared with the control group. A characteristic pattern of sICAM-1 variation with the timing of wounds was at its maximum level on the 3[rd] day post-trauma and then decreases towards its normal level. A number of factors were also compared with the sICAM-1 level and these included the nature of injury, the associated severe head injuries, and the combing bone affection with the soft tissue injuries. All the previously mentioned factors in the present work did not affect the characteristics pattern of sICAM-1 variation with the timing of wounds. Furthermore, sICAM-1 level was found to be significantly correlated with the degree of injury severity. It is recommended to use sICAM-1in the estimation of the timing of wounds in traumatized individuals