Immunological investigation of urinary protiens in Algerian diabetic patients

ABSTRACT

115 Juvenile and adult algerian diabetic patients were subjected for urine proteins investigation by gel electrophoresis and the immunoelectrophoresis. The results obtained were correlated with age of patients; duration of the disease; sex and type of treatment. In patients with diabetes for less than 5 years and proteinuria not more than 100 mg/dl, albumin; transferrin and ceruloplasmin were the protein components mostly excreted in urine and the proteinuria in such cases was described as selective. In patients with diabetes of more than 5 years and proteinuria exceeding 100 Mg/dl, additional relatively high molecular weight proteins including IgA and IgG were detected and the proteinuria in such cases can be considered as non selective. It is concluded that, selective proteinuria was encountered in young males as well as the same number of young females at the same age, whereas the non-selective proteinuria seems to be of higher frequency among adult female than adult male diabetics and it can be considered as a sign of advanced nephrotic ailment that would require much more intensive medical care