Studies of neurotransmitter mediating enzyme dopamine-B-hdroxylase, its cofactors and other biochemical parameters in the serum of diabetic heart disease patients

ABSTRACT

Neurotransmitter mediating enzyme Dopamine-beta-Hydroxylase [DBH], its cofactors and other biochemical parameters such as glucose, protein, albumin serum electrolytes, enzyme profiles, lipid profiles, urea, creatinine etc. are studied at six different age groups of both sexes, namely group I [10-l5 years], group II [15-25 years], group III [25-35 years], group IV [35-45 years] group V [45-55 years] and group VI [55+ years] of diabetic heart disease patients in comparison with the age matched controls. One unit of DBH activity is expressed in nmole/min/ml serum. DBH activity decreased in both males and females in groups I, II, III, IV, V and VI. The values of DBH activity in males and females are group I [19.95 units and 35.62 units], group II [21.42 units and 36.72 units], group III [26.48 units and 42.82 units], group IV [31.39 units and 51.53 units], group V [26.59 units and 17.95 units] and group VI [36.26 units and 41.53 units], respectively. One of the cofactors, ascorbic acid level slightly decreased in almost all groups. Another cofactor copper, increased in all groups. Triacylglycerol also increased in all the groups. HDL-cholesterol decreased in almost all the groups of both sexes, except in males of groups II, III and IV. Cholesterol and LDL-cholesterol were variabies. The cardiac enzymes such as CK-MB, GOT, LDH1 activity increased in all the groups. Other biochemical parameters such as protein, albumin, serum electrolytes, urea, creatinine, bilirubin etc. were increased in some groups and decreased in some groups, except urea, they were within their respective normal ranges