Hepatoprotection by Jigrine, a Unani herbal formulation, during country-made liquor-induced hepatotoxicity in rats
Hamdard Medicus. 2004; 47 (1): 85-88
in English
| IMEMR
| ID: emr-65965
ABSTRACT
The hepatoprotective potential of Jigrine tablets [a Unani polyherbal formulation containing a mixture of 14 medicinal plants] was evaluated in country-made liquor [CML]-induced hepatotoxicity in Wistar rats. The rats were made hepatotoxic by administering CML [3 ml/100 g/day in 2 divided doses] and corn oil [1 ml/100 g/day, in a single dose] orally for 21 days. The administration of Jigrine [200 mg/kg and 400 mg/kg] orally from day 15 to day 21 along with CML produced significant lowering [p<0.01] of serum AST, ALT, ALP, gamma-GTP and tissue lipid peroxide levels. The results were comparable to silymarin [25 mg/kg, orally]. The study shows that the Jigrine is definitely a hepatoprotective agent and reduction of liver damage by Jigrine treatment involved several mechanisms
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Plants, Medicinal
/
Rats, Wistar
/
Herbal Medicine
/
Liver
Limits:
Animals
Language:
English
Journal:
Hamdard Med.
Year:
2004
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