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Time course of degradation and deadenylation of maternal c-mos and cyclin A2 mRNA during early development of one-cell embryo in mouse
IBJ-Iranian Biomedical Journal. 2004; 8 (4): 179-183
in English | IMEMR | ID: emr-66014
ABSTRACT
Early in the development of many animals, before transcription begins, any change in the pattern of protein synthesis is attributed to a change in the translational activity or stability of mRNA in the egg and early embryo. As a result, translational control is critical for a variety of developmental decisions, including oocyte maturation and initiation of preimplantation development. In this study, using real-time RT-PCR method, we defined the time course of degradation and deadenylation of an oocyte specific gene [c-mos] more precisely and a gene that is re-synthesized after ZGA [cyclin A2]. Our data indicate that oocyte-specific transcript, c-mos, degrades rapidly while cyclin A2 mRNA does not and the deadenylation of c-mos mRNA precedes the process of degradation. Our findings suggest that time-dependent elimination of different maternal mRNA is a way for regulation of translation in early development of mouse embryos
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Index: IMEMR (Eastern Mediterranean) Main subject: RNA, Messenger / Genes, mos / Cyclin A / Embryonic Structures / Mice Limits: Animals Language: English Journal: Iran. Biomed. J. Year: 2004

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Index: IMEMR (Eastern Mediterranean) Main subject: RNA, Messenger / Genes, mos / Cyclin A / Embryonic Structures / Mice Limits: Animals Language: English Journal: Iran. Biomed. J. Year: 2004