Association of IFN- gamma gene polymorphism with type 1 diabetes in Iranian patients

ABSTRACT

Type 1 Diabetes [T1D] is a chronic and progressive autoimmune disorder. Cytokines play a critical role in the pathogenesis of T1D. IFN- polymorphism was investigated in T1D and compared with normal controls. Thirty patients suffering fromT1D and 40 normal controls were studied simultaneously using PCR technique. IFN- gene was evaluated at position 5'UTR +5644. There was a significant difference between patient and control groups in TT genotype [P<0.05]. In this study, we found a negative association between IFN- gene at position 5'UTR +5644 and T1D in Iranian patients pointing to T allele as a protective factor against T1D