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Inflammatory status in patients on chronic hemodialysis
JESN-Journal of Egyptian Society of Nephrology [The]. 2004; 7 (1): 117-124
in English | IMEMR | ID: emr-66513
ABSTRACT
All chronic renal failure patients show clinical and/or laboratory manifestations of inflammation. Prevalence of infection in chronic renal failure [CRF] patients is high due to immune dysfunction, also repeated cannulation and central venous catheters are probably responsible for the high incidence of infection. Detection of these pro-inflammatory cytokines in the plasma allow to detect patients with high risk of endotoxemia and also it was noticed that there is high degree of correlation between the inflammation, malnutrition and atherosclerotic process. The aim of the present study was to detect the level of plasma alpha-MSH as immunomodulator which counter acts the pro-inflammatory cytokines such as TNF-alpha, neopterin, nitric oxide [NO], C-reactive protein [CRP] and eridotoxins. This study was conducted on 40 subjects divided into three groups, 15 patients on maintenance hemodilaysis [GI], 15 patients with chronic renal failure not yet on dialysis [GII], and 10 healthy subjects as a control group [GIII]. Plasma alpha-MSH was measured using a double antibody radioimmunoassay, TNF-alpha and neopterin using specific enzyme-linked immunosorbent assays. Plasma nitrites were determined by a colorimetric method and endotoxin with the quantitative chromogenic method. The present study showed that most of the chronic renal failure patients show laboratory evidence of inflammation especially before starting dialysis. alpha-MSH was found to he elevated in both groups. Also, the levels of the proinflammatory cytokines, TNF-alpha, neopterin, nitric oxide, iNOS, C-reactive protein and plasma endotoxin were found to he elevated in both group I and group II. There was a positive correlation between alpha-MSH and endotoxemia. Also, there was a positive correlation between the level of endotoxins and the level of other pro-inflammatory cytokines suggesting the role of endotoxemia in stimulating the formation and release of the proinflammatory cytokines
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Index: IMEMR (Eastern Mediterranean) Main subject: C-Reactive Protein / Alpha-MSH / Cytokines / Neopterin / Tumor Necrosis Factors / Endotoxins / Inflammation Limits: Female / Humans / Male Language: English Journal: J. Egypt. Soc. Nephrol. Year: 2004

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Index: IMEMR (Eastern Mediterranean) Main subject: C-Reactive Protein / Alpha-MSH / Cytokines / Neopterin / Tumor Necrosis Factors / Endotoxins / Inflammation Limits: Female / Humans / Male Language: English Journal: J. Egypt. Soc. Nephrol. Year: 2004