Proteinurea and cerebrovascular stroke in type 2 diabetic patients

ABSTRACT

Proteinuria is an independent risk factor for cardiovascular disease in patients with NIDDM. The aim of this study was to assess the relationship between proteinuria and ischemic stroke in subjects with NIDDM, and to determine whether proteiuria is an independent risk factor for cerebrovascular stroke also. We performed a study on 20 diabetic patients with first-ever ischemic stroke due to thrombotic arterial occlusion, who were considered cases, and 10 diabetic patients without stroke, matched by gender. age, and diabetes duration, as a control group. WHO criteria for verified definite or possible stroke were used to ascertain the diagnosis of stroke. Proteinuria was higher in diabetics with stroke compared to those without stroke [P < 0.00]. Diabetic patients with stroke and proteinuria compared to those without proteinurea had significantly high duration of diabetes, systolic and diastolic blood pressure. fasting blood glucose, serum cholesterol and triglycerides[P < 0.05, 0.05, 0.001, 0.05, 0.05 and 0.01 respectively. However, proteinurea was not correlated to site, size or severity of stroke. In conclusion proteinurea was strongly associated with stroke in diabetic patients, may be through the presence of associated risk factors mainly hypertension. dyslipidemia and uncontrolled diabetes mellitus