Hypolipidemic activity of carvedilol, moxonidine and rilmenidine in experimentally-induced hyperlipidemia in rats

ABSTRACT

Hypertension remains the most common chronic disease in the industrialized world. Reduction of blood pressure is no longer the therapeutic goal of antihypertensive treatment. Hypertension is a well documented risk factor for dyslipidemia, coronary artery, cerbrovascular and renovascular diseases. Carvedilol, moxonidine and rilmenidine were investigated for their hypolipidemic effect in hyperlipidemic rats. All these drugs induced significant reduction in serum total cholesterol [TC], triglycerides [TG] and low density lipoproteins cholesterol [LDL-c], while high density lipoproteins cholesterol [HDL-c] was increased significantly in experimentally-induced hyperlipidemic rats. Also there is significant reduction in LDL-cHDL-c ratio. The obtained data indicate the beneficial effect of carvedilol, moxonidine and rilminidine as hypolipidemic drugs