Genotyping of human giardiasis in relation to anti - giardia secretory IgA and mucosal histopathology

ABSTRACT

Comparative study between the prevalence of pathological grading and giardia [groups I and I] genotypes revealed that out of patients having giardia genotype I, the prevalence of grade 0 was 13.16%, grade I was 21.05%, grade II was 47.37%, grade III was 13.16% and grade IV was 2.26% in comparison with 0%, 30.77%, 46.15%, 7.69% and 15.38% in genotype II [13 patients]; 10%, 40%, 20%, 20% and 10% in group III [10 patients]; 25%, 43.75%, 18.75%, 6.25% and 6.25% in mixed genotype infections group [16 patients] as well as 25%, 25%, 35.71%, 10.71% and 3.57% in undetermined infection group [28 patients] for grade 0, I, II, III and IV pathology respectively. There was no statistically significant difference regarding the prevalence of pathological grading in different giardia genotypes in Groups I and II. The means of OD of anti-giardia secretory IgA in relation to giardia genotypes in patients infected with giardia Groups I and II were significantly different, where 1.091 +/- 0.377, 1.079 +/- 0.474, 1.524 +/- 0.503, 1.292 +/- 0.472 and 1.004 +/- 0.31 groups of genotype I, II, III, mixed genotypes infection and undetermined infection group respectively], being more increased in patients infected with giardia genotype III and in mixed genotype infection