Examination of theta pulse effect on CA1 synaptic transmission in hippocampal slices of pentylenetetrazol - kindled rats

ABSTRACT

Effects of theta pulse stimulation [TPS] on CA1 synaptic transmission in pentylenetetrazol [PTZ] kindled rats were studied. PTZ [45 mg/kg] was injected every 48 hours to NMRI male rats. Hippocampal slices were prepared from control, partially and fully kindled rats. Theta pulse was delivered to Schaffer collaterals and recording was made from strata radiatum and pyramidale of CA1 region of hippocampal slices. PTZ kindling resulted in an enduring increase in fEPSP slope, but not OPS amplitude, in CA1 region of hippocampus. TPS decreased the amplitude of population spikes [PS] of partially and fully kindled rats which was significant in the latter as compared to controls. It is concluded that repeated administration of PTZ can change susceptibility of CA1 synapses to TPS