Association hepatite virale chronique C et purpura thrombopenique severe

ABSTRACT

Thrombocytopenia is a common extrahepatic manifestation of chronic viral hepatitis C. Many mechanisms are implicated in its genesis, specially the immunological factor. Several ways of treatment were used with a temporal efficiency. We reported an observation of a 62 year old female-pateint of chronic viral hepatitis C, who developed a severe thrombocytopenic purpura. Steroid therapy was ineffective. Treatment of such cases is difficult as association of immunosuppressive therapy increases the platelet count, but lad to severe hepatocellular insufficiency due to its negative effect on the hepatic function. Using other molecules as the immunoglobulines or interleukin II constitute a promising alternative way of treatment