Role of interferon-alpha, interleukin-1 beta and T cell activation in aplastic anemia pathogenesis
Medical Journal of Cairo University [The]. 2004; 72 (1): 59-64
in English
| IMEMR
| ID: emr-67563
ABSTRACT
The present work was performed to clarify the role of stimulatory cytokine as IL-1 beta and inhibitory cytokine as IFN-gamma and T cell activation evidenced by CD25 expression in the pathogenesis of aplastic anemia. Twenty-eight newly diagnosed aplastic anemia patients and 15 age and sex matched healthy controls were included in this study. An estimation of IL-1 beta, IFN-gamma and the percentage of CD25 expression was done to all patients and controls. IFN-gamma was significantly higher in AA patients as compared with the age matched controls. IL-1 beta was significantly lower in AA patients as compared with the controls. The percentage of CD25 expression was significantly higher in AA patients as compared with the controls. There was a highly positive significant correlation between IFN-gamma and leucocytopenia. There was a negative significant correlation between IL-1 beta and each of age and leucocytopenia. There was a highly positive correlation between CD25 expression and Hb level of the patients
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Receptors, Interleukin-2
/
Interferon-gamma
/
Interleukin-1
/
Erythrocyte Indices
/
Flow Cytometry
/
Anemia, Aplastic
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Med. J. Cairo Univ.
Year:
2004
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