Macrophage inflammatory protein 1 - alpha [MIP -I]: its pathogenetic role in some connective tissue diseases
Medical Journal of Cairo University [The]. 2004; 72 (Supp. 2): 257-67
in English
| IMEMR
| ID: emr-67670
ABSTRACT
This study aimed to measure serum level of macrophage inflammatory protein 1- alpha [MIP-la] in some connective tissue diseases as rheumatoid arthritis [RA], systemic lupus erythematosus [SLE] and systemic sclerosis [SSc] in order to clarify its possible role in their immunopathogenesis. Fifteen RA patients [group I], 15 SLE patients [group II], 10 SSc patients [group III] and 10 healthy controls [group IV] were participated in this study. A full history taking, thorough clinical examination and routine rheumatological profile investigations were done. Serum MIP-1-alpha was measured in all patients and control groups using ELISA technique. In conclusion, the higher level of serum MIP-1-alpha in RA, SLE and SSc patients could reflect its immunopathogenetic role as an important stimulator of T cells, monocyte macrophage as well as its variable pro-inflammatory activates
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Arthritis, Rheumatoid
/
Scleroderma, Systemic
/
Macrophage Inflammatory Proteins
/
Lupus Erythematosus, Systemic
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Med. J. Cairo Univ.
Year:
2004
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