Oxidative stress and cardiovascular diseases risk factors in hepatitis C infected hemodialysis patients

ABSTRACT

Oxidative stress which is defined as a disturbance of the normal balance between oxidants and antioxidants in the body, play a key role in accelerated atherosclerosis and to be involved in cardiovascular diseases [CVD] of dialyzed patients who are at the risk of increased oxidative stress. is to evaluate the effect of hepatitis C virus [HCV] infection and dialysis on oxidative stress markers Malondialdehyde [MDA], and its effect on increased CVD in HCV positive hemodialysis [HD]. 60 adults on maintenance HD patients were divided into 4 groups group-I 15 patients positive to HCV Ab with no clinical evidence of CVD; group-II 15 patients positive to HCV Ab with clinical evidence of CVD; group-III 15 dialysis patients negative to HCV Ab with no clinical evidence of CVD; group-IV 15 dialysis patients negative to HCV Ab with history of different CVD and Group V 15 healthy control subjects. all patients were subjected to full history and clinical examination, CXR, ECG, Echocardiography, routine laboratory investigations eg; BUN, creatinine, Lipid profile, ALT, AST, Albumin and measurement of serum MDA. MDA increase in all groups in comparison to control.- There is a strong correlation between MDA and CVD risk factors in groups II and IV than in other groups.- MDA increase with increasing years of dialysis.- There is a strong correlation between MDA and ALT in group-I and n and no correlation in groups III and IV. HD treatment is associated with rises in oxidative stress marker and the infection of HCV increases this effect. Oxidative stress is a strong factor in development of CVD in HD patients