Application of limulus amebocyte lysate [LAL] test for detecting endotoxin [pyrogen] in large volume parenterals
Pakistan Journal of Pharmaceutical Sciences. 2004; 17 (1): 89-4
in English
| IMEMR
| ID: emr-68041
ABSTRACT
Screening of twenty five large volume parenterals including dextrose, electrolytes, mannitol, metronidazole infusions, haemodialysis solution, water for injections and distilled water for the determination of pyrogen using Limulus Amebocyte Lysate [LAL] test has been carried out. Out of different preparations only one metronidazole injection exhibited positive LAL test, which was found pyrogen free with USP rabbit pyrogen test
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rabbits
/
Endotoxins
/
Infusions, Parenteral
/
Limulus Test
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2004
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