Haloperidol induced variations in hematological indices

ABSTRACT

It is essential for the effective management of drug action to understand the underlying pathogenesis of hematological dyscrasias. Hematological side effects of neuroleptic drugs occur infrequently but remain a potential cause of serious toxicity. The risk of butyrophenone induced blood dyscrasias seems to be underestimated in the literature, therefore we decided to report this as an animal model evaluation. The present work was undertaken to investigate the effect of typical antipsychotic drug [Haloperidol- 0.2mg/Kg], both as purified and commercially available form administered to rats [n=15], on hematological indices. Data of the present study suggests that the chronic administration of haloperidol may cause iron deficiency anemia. Although the morphological changes were more obvious in case of purified haloperidol treated rats as compared to the commercially available injections